INTERLEUKIN-10 INDUCES EXPRESSION OF CD39 ON CD8+T CELLS TO POTENTIATE ANTI-PD1 EFFICACY IN EGFR-MUTATED NON-SMALL CELL LUNG CANCER

Interleukin-10 induces expression of CD39 on CD8+T cells to potentiate anti-PD1 efficacy in EGFR-mutated non-small cell lung cancer

Background Anti-PD-1(L1) therapies are less efficacious in patients with EGFR-mutated non-small-cell lung cancer.However, the underlying mechanism is poorly understood.Methods The characteristics of T cells in EGFR-mutated and wild-type tumors were analyzed based on The Cancer Genome Atlas database and clinical samples.Plasma levels of 8 T-cell-rel

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Energy Aware Virtual Machine Scheduling in Data Centers

Power consumption is a primary concern in modern servers and data centers.Due to varying in workload types and intensities, different servers may have a different energy efficiency (EE) and energy proportionality (EP) even while having the same hardware configuration (i.e., central processing unit (CPU) generation and memory installation).For examp

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